Researchers reported that certain stem cells that were obtained from the bone marrow of adults could indicate whether that woman was capable of becoming pregnant or not. This finding could help prevent pregnancy loss, which is seen in some women.
These findings have provided a fresh perspective into understanding RPL or recurrent pregnancy loss. It affects anywhere between 1% and 2% of all couples. The cause of this disorder remains unclear in over 50% of cases, which is a constant source of worry for many.
Bone marrow-derived stem cells, these cells travel to the body’s uterus in high numbers once fertilization has occurred. These cells eventually become endometrial cells that form the uterine lining or decidua, which nourishes developing embryos & forms the placenta’s base. In case these cells are unable to function as intended, it could cause implantation failures, which could eventually lead to a miscarriage.
Progenitor cells located in the bone marrow are responsible for producing these blood cells. Once they’ve reached the uterus after fertilization, they transform into healthy endometrial cells, which make up the womb lining.
This current study tracked these cells during pregnancy and discovered that it made certain tracks in the uterus that adjoined implantation sites. The cells transformed into decidual cells or uterine endometrium that supports and nourishes the embryo and enable it to get in deep inside this lining, in a process called implantation. The cells finally form the placenta’s maternal side.
Researchers had earlier developed an innovative transplant procedure involving the bone marrow that could destroy these rogue cells but allow the ovaries to retain their function. This was achieved via the usage of antimetabolites, which are a chemotherapeutic drug class, which don’t poison cells but cut them off from certain components vital for cell reactions.
The researchers concluded that the findings of this study could help understand and come up with new treatments for RPL.